Beilstein J. Org. Chem.2018,14, 930–954, doi:10.3762/bjoc.14.80
, including important PDCs that have progressed to phase III clinical trials. Last, we address possible difficulties that may emerge during the synthesis of PDCs, as also report ways to overcome them.
Keywords: bioconjugates; cancer; drug delivery; PDC; peptide; peptide–drug conjugate; side-productsinPDCs
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Graphical Abstract
Figure 1:
Conventional chemotherapy versus targeted chemotherapy. Black color = Solid malignant tumor; red = ...